Ideas for BioData Catalyst from the scientific researcher community

PheWAS Analysis

DataSTAGE should curate all available GWAS scan results available in GWAS catalog (, the NCBI archie (, and other privately held repositories (eg GIANT and T2D portal , Broad Inst) to enable PheWAS analysis. Biological insight can be gained in looking at the pleiotropic effects of specific variants that can suggest appropriate functional followup studies, or suggest relevant biological pathways. Machine learning tools can be developed to mine these results data to find new patterns. Prospectively, collect and archive GWAS results generated on DataSTAGE for lookup and PheWAS analysis. Investigators looking for biological interpretation of association results, as well as insights that may suggest novel therapeutic targets would benefit. This is towards translation.



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Idea No. 3